OLS Bioinformatics for Biologists Seminar Series - Inaugural Seminar

Rapid Protein Structure Database Searching: A Filter-and-Refine Approach

SPEAKER: Zeyar Aung, Research Fellow, Institute for Infocomm Research
TIME: Tuesday September 25, 2007, 4 PM
VENUE: Block S2 Level 4 Seminar Room 1

ABSTRACT: As protein databases continue to grow in size, exhaustive search methods that compare a query structure against every database structure can no longer provide satisfactory performance. Instead, the filter-and-refine paradigm offers an efficient alternative to database search without compromising the accuracy of the answers. In this paradigm, protein structures are represented in an abstract form. During querying, based on the abstract representations, the filtering phase prunes away dissimilar structures quickly so that only a small collection of promising structures are examined using a detailed structure alignment technique in the refinement phase. In this talk, we will cover an overview of the existing methods developed for the filtering phase, and discuss the techniques that we have proposed for both the filtering and the refinement phases.

ABOUT THE SPEAKER: Zeyar Aung received his Ph.D. in Computer Science from the National University of Singapore in 2006. He is currently a Research Fellow at the Institute for Infocomm Research, A*STAR, Singapore. His research interests include bioinformatics, cheminformatics, data mining, and database indexing and retrieval. He is a member of the Life Sciences Society.



ABOUT THE OLS BIOINFORMATICS FOR BIOLOGISTS SEMINAR SERIES:

The "virtuous cycle" of bioinformatics is revolutionizing the biomedical sciences. Computational biologists produce analytical and predictive bioinformatics tools that are increasingly used to guide wet-lab research. In turn, the wet-lab biologist has valuable experience, knowledge and data that can be used to refine those bioinformatics tools.

The OLS Bioinformatics for Biologists seminar series will bring together wet-lab and computational biologists from NUS, in an informal setting, to promote collaborations and exchange of ideas. Selected NUS computational biologists whose research has practical application to wet-lab biology will present their work. Active exchange of information during the seminar is encouraged.


Contact: Susan J. Moore / Last updated: 19 September 2007.