Peptide-Binding Prediction

• TRAP-559AA (HLA-A11 targets)

  mnhlgnvkylvivfliffdlflvngrdvqnnivdeikyseevcndqvdlyllmdcsgsirrhnwvnhavp
  lamkliqqlnlndnaihlyVNVFSNNAKeiirlhsdasknkekaliiirsllstnlpygrtnltdallqv
  rkhlndrinrenanqlvviltdgipdsiqdslkesrklsdrgvkiavfgigqginvafnrflvgchpsdg
  kcnlyadsawenvKNVIGPFMKAVCVEVEKtascgvwdewspcsvtcgkgtrsrkreilhegctseiqeq
  ceeercppkwepldvpdepeddqprpRGDNSSVQKpeeniidnnpqepspnpeegkdenpngfdldenpe
  nppnpdipeqkpnipedsekevpsdvpknpeddreenfdipkkpenkhdnqnnlpndksdrnIPYSPLPP
  Kvldnerkqsdpqsqdnngnrhvpnsedretrphgrnnenrsynrkyndtpkhpereehekpdnnkkkge
  sdnkykiaggiagglalLACAGLAYKfvvpgaatpyagepapfdetlgeedkdldepeqfrlpeenewn
  

• Only a few peptides have the right shape to fit into some MHC molecules
• These are targets for vaccines and immunotherapeutic drugs
• Finding them are slow and expensive in wet laboratories
• So we predict them by training neural networks on a large proprietary warehouse of binding/non-binding information.